Reaction of 2-aminopyrimidines with αhalocarboxylic acids and their esters

N-Pyrimidylcarboxylic acids and their esters, which can be cyclized to tetrahydromidazo-[1,2-a]pyrimidine-2,5-diones, are formed from 2-aminopyrimidine and its C-substituted derivatives by reaction with -halo acids and their esters under mild conditions. Alkylation proceeds at the N₁ and N₃ atoms of the pyrimidine ring during the action of unsymmetrical 2-aminopyrimidines with -halo acids.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1140–1142, August, 1974.