Purinenucleoside analogs. 2. 9-(1-Alkoxyethyl-1)-6-substituted purines |
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Authors: | M A Madre R A Zhuk M Yu Lidak |
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Institution: | (1) Institute for Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006 Riga |
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Abstract: | Vinyl ethers react with 6-chloro- and 6-methylthiopurines in acid medium to give 9-(1-alkoxyethyl-1)-6-chloro- and 6-methylthiopurines. The 6-chloro compounds were used to prepare 9-(1-alkoxyethyl-1)-6-mercaptopurines. All the synthesized compounds proved to be inactive against lympholeucosis P 388, and Lewis carcinona grafted under kidney capsules in mice.For Communication 1, see 1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 403–406, March, 1986. |
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