| Study on the Synthesis of Metabolite of Clausenamide （CM1） |
| |
| 引用本文： | Xing Zhou LI,Ke Mei WU,Dao Fei HUANG,Liang HUANG* Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College. 1 Xian Nong Tan St. Beijing 100050. Study on the Synthesis of Metabolite of Clausenamide （CM1）[J]. 中国化学快报, 2002, 13(6): 528-530 |
| |
| 作者姓名： | Xing Zhou LI Ke Mei WU Dao Fei HUANG Liang HUANG* Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College. 1 Xian Nong Tan St. Beijing 100050 |
| |
| 作者单位： | Xing Zhou LI，Ke Mei WU，Dao Fei HUANG，Liang HUANG* Institute of Materia Medica，Chinese Academy of Medical Sciences & Peking Union Medical College. 1 Xian Nong Tan St. Beijing 100050 |
| |
| 摘 要： | (-) Clausenamide (1) showed strong nootropic action, while its (+) antipode had no such an action. The content of CM1(2) in the metabolites of (-)1 is much higher than that of (+)11. For comparing the nootropic activity of enantiomers, (+) and (-) CM1 were synthesized. CM1 is the hydroxylated product of the N-methyl group of clausenamide. Oxidation of the C3-OH and C6-OH protected clausenamide to introduce the hydroxyl group into the methyl was tried but unsuccessful. Then de novo s…
|
| 关 键 词： | 合成 代谢物 CMI 酰胺 |
Study on the Synthesis of Metabolite of Clausenamide ( CM1) |
| |
| Xing Zhou LI,Ke Mei WU,Dao Fei HUANG,Liang HUANG. Study on the Synthesis of Metabolite of Clausenamide ( CM1)[J]. Chinese Chemical Letters, 2002, 13(6): 528-530 |
| |
| Authors: | Xing Zhou LI Ke Mei WU Dao Fei HUANG Liang HUANG |
| |
| Abstract: | (+)CM1, (-)CM1 as well as (±)CM1–the metabolites of clausenamide were synthesized from (-phenyl-(N-p-methoxylbenzyl)-ethanol amine through 8 and 6 steps respec-tively. |
| |
| Keywords: | Metabolite clausenamide intramolecule cyclization debenzylation hydroxymethy- lation. |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
