Concise syntheses of trifluoromethylated cyclic and acyclic analogues of cADPR |
| |
| Authors: | Huang Xiangchen Dong Min Liu Jian Zhang Kehui Yang Zhenjun Zhang Liangren Zhang Lihe |
| |
| Affiliation: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. |
| |
| Abstract: | A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
