Simplifying native chemical ligation with an N-acylsulfonamide linker |
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| Authors: | Burlina Fabienne Morris Caroline Behrendt Raymond White Peter Offer John |
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| Affiliation: | UPMC Univ Paris 06, CNRS, ENS, UMR 7203 Laboratoire des Biomolécules, 4 place Jussieu, 75005 Paris, France. |
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| Abstract: | We report a simplified procedure for the chemical ligation of peptides by using the sulfamylbutyryl linker as a mildly activating group capable of participating in ligation. When the peptidyl N-methylsulfonamide is directly added with excess thiols to ligation reactions, the speed of reaction is comparable to native chemical ligation. |
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