Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties |
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| Authors: | Kellett Andrew O'Connor Mark McCann Malachy McNamara Mary Lynch Patrick Rosair Georgina McKee Vickie Creaven Bernie Walsh Maureen McClean Siobhan Foltyn Agnieszka O'Shea Denis Howe Orla Devereux Michael |
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| Affiliation: | The inorganic pharmaceutical and biomimetic research centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin, 8, Ireland. andrew.kellett@dit.ie |
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| Abstract: | Three, structurally characterised, bis-phen Cu(II) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A-T)](2) and Poly[d(G-C)](2) binding. |
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