Synthesis and structure of copper(II) coordination compounds with 8-quinolinecarboxaldehyde thio- and 4-phenylthiosemicarbazones |
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| Authors: | M D Revenko P N Bourosh E F Stratulat M Gdaniec Ya Lipkowski I D Korzha Yu A Simonov |
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| Institution: | 1.Moldova State University,Chisinau,Moldova;2.Institute of Applied Physics,Academy of Sciences of Moldova,Chisinau,Moldova;3.Department of Chemistry,Mickiewicz University,Poznan,Poland;4.Institute of Physical Chemistry,Polish Academy of Sciences,Warsaw,Poland |
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| Abstract: | 8-Quinolinecarboxaldehyde thiosemicarbazone (HL) and copper form compounds with a metal: ligand ratio of 1: 1 in which the
ligand is either the neutral molecule or the monohydric acid anion. Its acidic properties are enhanced not only as a result
of coordination but also due to the electronic effect of substituents in the thiosemicarbazide moiety. 8-Quinolinecarboxaldehyde
4-phenylthiosemicarbazone (HL1) is coordinated only as the anion. The structures of Cu(HL)SO4]2, Cu(L)NO3]2, and Cu(L1)NO3]2 · 0.25H2O, and free HL1 were studied. The tendency of the complexes to dimerization and association with acid anions or sulfur atoms of the organic
ligands as bridges was established. In binuclear compounds with closely spaced magnetic centers, no exchange interaction between
them was found. The copper coordination compounds with HL are able to suppress the growth of cancer cells 41M and SK-BR-3
and are promising objects for investigation as anticancer drugs. |
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