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On the possibility of determining anthracycline antibiotics in aqueous solutions using optical analytical system (biosensor) |
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| Authors: | Yu. M. Yevdokimov S. G. Skuridin V. I. Salyanov S. V. Semenov P. N. Sol’ev V. T. Valuev-Elliston F. V. Vereshchagin D. P. Chulkov O. N. Kompanets |
| Affiliation: | 1.Engelhardt Institute of Molecular Biology,Russian Academy of Sciences,Moscow,Russia;2.Russian Research Centre Kurchatov Institute,Troitsk, Moscow,Russia;3.Institute of Spectroscopy,Russian Academy of Sciences,Troitsk, Moscow,Russia |
| Abstract: | We propose a version of the theory describing the circular dichroism spectra of cholesteric liquidcrystal dispersion particles of double-stranded DNA. The basis of the theory is the concept of absorption of electromagnetic waves by large molecular systems. The effect of physical parameters of dispersion particles on their circular dichroism is theoretically determined. It is experimentally demonstrated that circular dichroism can be used as a convenient tool for creating an optical analytical system for the determination of biologically active compounds that interact with DNA molecules. |
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