| Abstract: | The N-terminal sequence of Luffaculin 1 was determined to be Asp-Val-Ser-Phe-Ser- . The CD spectrum of Luffaculin 1 indicated that Luffaculin 1 contains the 37.1%α-helix , 33.4% β-sheet,and 29.5% random coil. N-glycosidase activity of Luffaculin 1 against animal rRNA is observed. The anti-tumor activity of Luffaculin 1 on cell strains B16, MGC, Bel were determined,giving IC50 of 1.78×10-7mol/L,2.11×10-7mol/L,and 4.21×10-7mol/L,respectively. We also discussed the N-terminal sequences, secondary structures, and bioactivities of Luffaculin 1 against Trichosanthin. |
