Facile synthesis of 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones |
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Authors: | Rajab Abu-El-Halawa Alaa Sarabi and Mustafa M El-Abadelah |
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Institution: | (1) Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat, 395 007, Gujarat, India |
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Abstract: | Interaction between 2,5-dichlorothiophene-3-carbonyl isothiocyanate, accessible via 2,5-dichlorothiophene-3-carbonyl chloride, and model heterocyclic amines produced the respective 2,5-dichloro-N-(substituted aminocarbonothioyl)thiophene-3-carboxamides. Upon heating, the deprotonated form of the latter underwent intramolecular
cyclization to deliver the corresponding 2-(substituted amino)-4H-thieno3,2-e]-1,3-thiazin-4-ones. The structures of these new bicyclic derivatives and their acyclic precursors are based on microanalytical
and spectral (IR, MS, and NMR) data. |
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