Effects of the N-methyl-D-Aspartate receptor antagonist dextromethorphan on vibrotactile adaptation |
| |
| Authors: | Stephen E Folger Vinay Tannan Zheng Zhang Jameson K Holden Mark Tommerdahl |
| |
| Institution: | (1) Department of Physical Therapy Education, Elon University, 27244 Elon, NC, USA;(2) Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, 27599, North Carolina, USA |
| |
| Abstract: | Background Previous reports have demonstrated that short durations of vibrotactile stimuli (less than or equal to 2 sec) effectively
and consistently modify both the perceptual response in humans as well as the neurophysiological response in somatosensory
cortex. The change in cortical response with adaptation has been well established by a number of studies, and other reports
have extended those findings in determining that both GABA- and NMDAR-mediated neurotransmission play a significant role in
the dynamic response of somatosensory cortical neurons. In this study, we evaluated the impact that dextromethorphan (DXM),
an NMDAR antagonist, had on two distinct vibrotactile adaptation tasks. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
