| Abstract: | Methods have been developed for obtaining soluble and insoluble dextran carbonates. The addition of the latter to E. coli L-asparaginase has given water-soluble, gel-like, and insoluble forms of the immobilized enzyme. The influence of the bound polymer on some physicochemical properties of L-asparaginase has been determined. The antileukemic action of soluble dextran derivatives of L-asparaginase has shown that their efficiency is greater than that of the native enzyme.A. Kirkhenshtein Institute of Microbiology, Latvian Academy of Sciences, Riga. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 432–436, May–June, 1993. |
