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Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues
Authors:Biron Eric  Chatterjee Jayanta  Ovadia Oded  Langenegger Daniel  Brueggen Joseph  Hoyer Daniel  Schmid Herbert A  Jelinek Raz  Gilon Chaim  Hoffman Amnon  Kessler Horst
Affiliation:1. CIPS at Department Chemie, Technische Universit?t München, Lichtenbergstrasse 4, 85747‐Garching, Germany, Fax: (+49)?892‐891‐3210;2. Equal contribution.;3. Department of Pharmaceutics and Organic Chemistry, Hebrew University, Jerusalem, Israel;4. Novartis Institutes of Biomedical Research, Basel, Switzerland;5. Department Chemistry, Ben‐Guiron University, Beersheba, Israel
Abstract:
Keywords:bioavailability  cyclic peptides  N methylation  peptide drugs  somatostatin
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