A facile route to a versatile synthon for preparation of cis-pyrethroids |
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Authors: | James H. Babler Benedict J. Invergo |
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Affiliation: | Department of Chemistry, Loyola University of Chicago Chicago, Illinois 60626 USA |
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Abstract: | -2-Cyano-3,3-dimethylcyclopropanecarboxylic acid was obtained in >50% overall yield starting with ethyl 3,3-dimethylacrylate. The key step involved a tandem Michael reaction - intramolecular displacement to afford stereoselectively a cyclopropanoid precursor of -pyrethroids. |
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