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A facile route to a versatile synthon for preparation of cis-pyrethroids
Authors:James H. Babler  Benedict J. Invergo
Affiliation:Department of Chemistry, Loyola University of Chicago Chicago, Illinois 60626 USA
Abstract:cis-2-Cyano-3,3-dimethylcyclopropanecarboxylic acid was obtained in >50% overall yield starting with ethyl 3,3-dimethylacrylate. The key step involved a tandem Michael reaction - intramolecular displacement to afford stereoselectively a cyclopropanoid precursor of cis-pyrethroids.
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