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A new approach to the synthesis of phosphotriester intermediates of nucleosides and nucleic acids |
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| Authors: | G van der Marel CAA van Boeckel JH van Boom |
| Institution: | Gorlaeus Laboratory, P.O.Box 9502, 2300 RA Leiden, The Netherlands |
| Abstract: | Aryl phosphorodichloridates can be converted by means of 1-hydroxybenzotriazole into an effective phosphorylating agent, which can be applied to the synthesis of phosphotriester intermediates of nucleic acids. |
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