Enhancement of intracellular γ-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis,isoprostane formation,and tocopherol oxidation |
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| Authors: | Yuichiro Tanaka Leslie A Lesoon Wood Robert V Cooney |
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| Institution: | (1) University of Hawaii Cancer Research Center, Natural Products and Cancer Biology Program, 1236 Lauhala Street, Honolulu, 96813, Hawaii |
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| Abstract: | Background Stimulation of C3H 10T1/2 murine fibroblasts with interferon-γ(IFN) and bacterial lipopolysaccharide (LPS) generates reactive
oxygen and nitrogen species leading to DNA damage, lipid oxidation, and tocopherol oxidation. The tocopherols possess unique
chemical and biological properties that suggest they have important roles related to intracellular defense against radical-mediated
damage. |
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| Keywords: | |
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