四环素类抗菌素碱性降解物与碱土金属螯合物的荧光研究

临床医学发现,给病人服用四环素后定时测定体液中四环素含量,可以诊断胃癌~1],因此.建立灵敏、准确的四环素测定方法具有重要意义.已知四环素类抗菌素与一些金属离子有很强的螯合能力,并能生成有色螯合物,其中以锆、钍、铀、锌、铜、铝、镁、铈及钴的螯合物尤为稳定,可用于鉴别、测定四环素类抗菌素的含量.一些螯合物也用于荧光测定~2～6],但

Fluorimetric Studies on Complexes of Tetracycline Antibiotics Degradation Products with Alkaline Earth Metals

This paper first describes the sensitive detections of tetracycline antibiotics,which are propertional to the fluorescent intensities of complexes of their alkaline degradation products with alkaline earth metals.The structures of the complexes and the interferences of coexisting ions are discussed.This method are useful in clinical assay and diagnosis.