Unusual behaviour of N‐cinnamoyl‐2‐hydroxy‐2‐(trifluoromethyl)‐arylethylamines in pictet‐gams cyclization. Synthesis of 2‐styryl‐5‐aryl‐5‐trifluoromethyl‐2‐oxazolines |
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Authors: | LSzl
Poszvcz Gyula Simig |
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Institution: | LÁSzlÓ Poszávácz,Gyula Simig |
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Abstract: | Cyclization of N‐acyl‐2‐hydroxy‐2‐(trifluoromethyl)arylethylamines 4 under Pictet‐Gams conditions afforded 2‐oxazolines 5 instead of the expected isoquinolines 6 . The effect of the trifluoromethyl group on the result of the reaction is discussed. |
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