| 生理盐水中牛血清白蛋白与碳酸钙的相互作用研究 |
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| 引用本文： | 谢安建,沈玉华,张胜义,谢复新. 生理盐水中牛血清白蛋白与碳酸钙的相互作用研究[J]. 无机化学学报, 2001, 17(4): 603-607 |
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| 作者姓名： | 谢安建 沈玉华 张胜义 谢复新 |
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| 作者单位： | 安徽大学化学化工学院 |
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| 基金项目： | 国家自然科学基金资助项目(No.20031010,29971001),国家教育部重点项目(No.00180)以及安徽省自然科学基金资助项目(No.0045115). |
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| 摘 要： | 珍珠、贝壳和甲壳是生物矿化的产物，具有高强度、高韧性。人们已对它们的组成、结构等进行了大量的研究犤１～４犦。结果表明，它们的主要成分是碳酸钙，但由于含有少量的蛋白质等有机基质，使其结构具有特殊的组装方式，从而显示出与纯碳酸钙迥然不同的优良物理性质和重要的生物功能。另一些研究表明胆结石、尿结石等异常生物矿化产物中也含有一定量的碳酸钙犤５犦。然而生物矿化过程非常复杂，其机理至今尚无统一说法。因此模拟生物矿化过程，了解有机基质在矿化过程中的作用，已成为化学、生物、医学和材料等多学科相互渗透和相互交叉的…
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| 关 键 词： | 牛血清白蛋白 碳酸钙 相互作用 生物矿化 生理盐水 |
| 收稿时间： | 2001-03-22 |
| 修稿时间： | 2001-03-22 |
Study on Interactions between BSA and Calcium Carbonate in Saline Solution |
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| XIE An-Jian,SHEN Yu-Hu,ZHANG Sheng-Yi and XIE Fu-Xin. Study on Interactions between BSA and Calcium Carbonate in Saline Solution[J]. Chinese Journal of Inorganic Chemistry, 2001, 17(4): 603-607 |
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| Authors: | XIE An-Jian SHEN Yu-Hu ZHANG Sheng-Yi XIE Fu-Xin |
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| Affiliation: | College of Chemistry and Engineering, Anhui University, Hefei 230039,College of Chemistry and Engineering, Anhui University, Hefei 230039,College of Chemistry and Engineering, Anhui University, Hefei 230039 and College of Chemistry and Engineering, Anhui University, Hefei 230039 |
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| Abstract: | In this paper, Fourier transform infrared spectroscopy and inductively coupled plasma atomic emission spectrometry were used to study the filtrates produced by reactions of different initial mole ratios of bovine serum albumin (BSA) and calcium carbonate (CaCO3) in saline solution. The results demonstrated that there were strong interactions between BSA and calcium carbonate by hydrogen bonds or coordination or electrostatic attraction, which made the solubility of calcium carbonate in aqueous solution increased and the microstructure of BSA and CaCO3 changed. The interaction helped to form biomineral containing protein and CaCO3 in organism. |
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| Keywords: | bovine serum albumin calcium carbonate interaction biomineralization |
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