Synthesis of cancer peptide antigen-lipid A analog conjugates for synthetic vaccines. |
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| Authors: | K Ikeda K Miyajima Y Maruyama K Achiwa |
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| Affiliation: | School of Pharmaceutical Sciences, University of Shizuoka, Japan. |
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| Abstract: | Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3. |
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