Complexation of L-lactate with boronic acids: a solution and holographic analysis |
| |
Authors: | Sartain Felicity K Yang Xiaoping Lowe Christopher R |
| |
Affiliation: | Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK. |
| |
Abstract: | Boronic acids have been used as receptors for the detection of diols and alpha-hydroxy acids. The incorporation of 3-acrylamide phenyl boronic acid (3-APB) into a hydrogel generates a suitably responsive and fully reversible holographic sensor for L-lactate. However, it was also found that the use of 3-APB resulted in the sensor being responsive towards a number of other compounds containing two hydroxy groups. This report details the further investigation into the reaction between L-lactate and three boronic acid-based receptors, both in the holograms and in solution, in order to establish the mechanism of binding. A novel boronate receptor is proposed based on this understanding. |
| |
Keywords: | boronic acid lactate ligands receptors sensors |
本文献已被 PubMed 等数据库收录! |
|