| 2-甲基-1,8-萘啶衍生物的甲基溴代反应 |
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| 引用本文： | 苟高章,吴娜,石玲,徐世娟,严和平,刘卫.2-甲基-1,8-萘啶衍生物的甲基溴代反应[J].应用化学,2014,31(11):1268-1272. |
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| 作者姓名： | 苟高章 吴娜 石玲 徐世娟 严和平 刘卫 |
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| 作者单位： | (1.红河学院理学院 蒙自 661100;
2.云南省天然药物与化学生物学重点实验室,红河学院 蒙自 661100) |
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| 基金项目： | 国家自然科学基金资助项目，云南省应用基础研究计划自筹项目，云南省化学硕士点建设学科资助项目，the National Natural Science Foundation of China，the Scientific Research Foundation of Education Department of Yunnan Province，the Chemistry of Key Construction Disciplines for Master Degree Program in Yunnan |
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| 摘 要： | 报道了2-甲基-1,8-萘啶衍生物的甲基溴化反应，以N-溴代琥珀酰亚胺(NBS)为溴化剂、红外光为引发剂，得到单溴代产物2-溴甲基-1,8-萘啶衍生物及其二溴代副产物2-二溴甲基-1,8-萘啶衍生物，对比了两种不同的反应条件，通过对影响甲基溴化产物产率的反应条件进行优化改进，得到单溴代产物的较优合成条件为：NBS的用量为原料的1.2倍，500 W红外灯为光源，反应时间为2 h。 该反应条件下，单溴代产物的产率可达到54.6%。
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| 关 键 词： | 萘啶 N-溴代琥珀酰亚胺 引发剂 |
| 收稿时间： | 2013-12-18 |
| 修稿时间： | 2014-04-29 |
Bromination of 2-Methyl-1, 8-naphthyridine Derivatives |
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| GOU Gaozhang,WU Na,SHI Ling,XU Shijuan,YAN Heping,LIU Wei.Bromination of 2-Methyl-1, 8-naphthyridine Derivatives[J].Chinese Journal of Applied Chemistry,2014,31(11):1268-1272. |
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| Authors: | GOU Gaozhang WU Na SHI Ling XU Shijuan YAN Heping LIU Wei |
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| Institution: | (1.College of Science;2.Key Laboratory of Natural Pharmaceutical & Chemical Biology of ;
Yunnan Province,Honghe University,Mengzi 661100,China) |
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| Abstract: | This paper reported the bromination of 2-methyl-1,8-naphthyridine derivatives. Monobrominated products, 2-bromomethyl-1,8-naphthyridine derivatives, and dibrominated byproducts were obtained with N-bromosuccimide(NBS) as the bromination agent under infrared light. Two synthetic conditions were evaluated. The yield of monobrominated products is up to 54.6% under the optimized condition of 2-methyl-1,8-naphthyrdine derivatives and NBS in molar ratio of 1∶1.2 under 500 W infrared light. |
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| Keywords: | naphthyridine N-bromosuccinimide initiator |
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