| 双手性噁唑硼烷体系催化还原反应的研究 |
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| 引用本文： | 王琳,魏峰,张小霞,崔欣,陈代谟. 双手性噁唑硼烷体系催化还原反应的研究[J]. 合成化学, 2003, 11(4): 284-285 |
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| 作者姓名： | 王琳 魏峰 张小霞 崔欣 陈代谟 |
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| 作者单位： | 中国科学院成都有机化学研究所,不对称合成四川省重点实验室,四川,成都,610041 |
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| 摘 要： | 第一次成功设计、合成了新型的双手性噁唑硼烷还原体系，并将其应用于前手性酮的不对称还原。实验结果表明，双手性噁唑硼烷体系在手性相匹配的情况下，对前手性酮还原的对映选择性明显地优于单手性的噁唑硼烷的还原体系。
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| 关 键 词： | 双手性 噁唑硼烷 催化还原反应 不对称合成 催化剂 1 3 2-噁唑硼烷 |
| 文章编号： | 1005-1511(2003)04-0284-02 |
| 修稿时间： | 2003-05-21 |
Asymmetric Reduction of Representative Ketones with a Bis-chiral Oxazaborolidine System |
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| WANG Lin,WEI Feng,ZHANG Xiao xia,CUI Xin,CHEN Dai mo. Asymmetric Reduction of Representative Ketones with a Bis-chiral Oxazaborolidine System[J]. Chinese Journal of Synthetic Chemistry, 2003, 11(4): 284-285 |
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| Authors: | WANG Lin WEI Feng ZHANG Xiao xia CUI Xin CHEN Dai mo |
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| Abstract: | A new bis chiral oxazaborolidine reduction system has been designed and synthesized firstly by author. The new system has been applied to the asymmetric catalytic reduction of proketones. Significantly higher enantioselectivity was observed in the reduction of representative ketones with our system in comparison with the common oxazaborolidine system. |
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| Keywords: | asymmetric reduction bis chiral oxazaborolidine ketones |
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