Lewis acid mediated reactions of aldehydes with styrene derivatives: synthesis of 1,3-dihalo-1,3-diarylpropanes and 3-chloro-1,3-diarylpropanols |
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Authors: | Kabalka George W Wu Zhongzhi Ju Yuhong Yao Min-Liang |
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Affiliation: | Department of Chemistry, The University of Tennessee, Knoxville, Tennessee 37996-1600, USA. kabalka@utk.edu |
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Abstract: | [reaction: see text] The reactions of aryl aldehydes with styrene derivatives, mediated by various boron Lewis acids, were investigated. 1,3-Dihalo-1,3-diarylpropanes were obtained in high yields with boron trihalides, while 3-chloro-1,3-diarylpropanols were obtained in good to excellent yields with phenylboron dichloride. Reactions involving nonenolizable aliphatic aldehydes, trans-cinnamaldehyde, and beta-substituted styrenes were also investigated for the first time. |
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