亲水性二苯甲胺树脂制备及用于肽合成研究 |
| |
引用本文: | 程晓辉,阎虎生,倪爱国,何炳林. 亲水性二苯甲胺树脂制备及用于肽合成研究[J]. 化学学报, 1993, 51(10): 1005-1009 |
| |
作者姓名: | 程晓辉 阎虎生 倪爱国 何炳林 |
| |
作者单位: | 南开大学高分子化学研究所,南开大学高分子化学研究所,南开大学高分子化学研究所,南开大学高分子化学研究所 天津 300071,天津 300071,天津 300071,天津 300071 |
| |
摘 要: | 通过反相悬浮共聚合成了含酯基的聚丙烯酰胺树脂, 再经乙二胺取代和两步缩合反应引入二苯甲胺功能基团。讨论了反应条件对各步反应的影响。测定了该载体与几种保护氨基酸的缩合率并合成了模型肽。缩合率和模型肽的纯度都令人满意。
|
关 键 词: | 合成 聚丙烯酰胺 多肽 亲水性 二苯甲胺基树脂 |
Preparation of hydrophilic benzhydrylamine resin and its application in solid phase peptide synthesis |
| |
Abstract: | Ester group-contg. polyacrylamide resin was prepared with reverse phase suspension copolymn.; the benzhydrylamine groups were introduced to the polymer by ethylenediamine substitution and two-step condensation. The effect of reaction conditions was studied. With the use of the prepared support, a model peptide was synthesized. Condensation yields in the peptide synthesis were measured. The yields and purity of the peptide were satisfactory. |
| |
Keywords: | SYNTHESIS POLYACRYLAMIDE POLYPEPTIDE HYDROPHILICITY |
本文献已被 CNKI 维普 等数据库收录! |
| 点击此处可从《化学学报》浏览原始摘要信息 |
|
点击此处可从《化学学报》下载全文 |