Treatment of trigeminal ganglion neurons in vitro with NGF,GDNF or BDNF: effects on neuronal survival,neurochemical properties and TRPV1-mediated neuropeptide secretion |
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| Authors: | Theodore?J?Price Michael?D?Louria Damaries?Candelario-Soto Gregory?O?Dussor Nathanial?A?Jeske Amol?M?Patwardhan Anibal?Diogenes Amanda?A?Trott Kenneth?M?Hargreaves Email author" target="_blank">Christopher?M?FloresEmail author |
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| Institution: | (1) Department of Pharmacology, The University of Texas Health Science Center at San Antonio, USA;(2) Department of Endodontics, The University of Texas Health Science Center at San Antonio, USA;(3) Johnson and Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean Roads, Spring House, 19477-0776 PA, USA |
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| Abstract: | Background Nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF)
all play important roles in the development of the peripheral sensory nervous system. Additionally, these growth factors are
proposed to modulate the properties of the sensory system in the adult under pathological conditions brought about by nerve
injury or inflammation. We have examined the effects of NGF, GDNF and BDNF on adult rat trigeminal ganglion (TG) neurons in
culture to gain a better understanding of how these growth factors alter the cytochemical and functional phenotype of these
neurons, with special attention to properties associated with nociception. |
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