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Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs |
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| Authors: | Tamamura Hirokazu Tsutsumi Hiroshi Masuno Hiroyuki Mizokami Satoko Hiramatsu Kenichi Wang Zixuan Trent John O Nakashima Hideki Yamamoto Naoki Peiper Stephen C Fujii Nobutaka |
| Affiliation: | Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Japan. tamamura.mr@tmd.ac.jp |
| Abstract: | A linear type of several low molecular weight CXCR4 antagonists were developed based on T140 analogs, which were previously found to be strong CXCR4 antagonists that block X4-HIV-1 entry and have inhibitory activities against cancer metastasis/progression and rheumatoid arthritis. |
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