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Two new paeciloxocins from a mangrove endophytic fungus Paecilomyces sp. |
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| Authors: | Wen Lu Chen Gang She Zhigang Yan Chunyan Cai Juanni Mu Lei |
| Institution: | 1.College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China ;2.School of Chemical and Chemical Engineering, Sun Yat- Sen (Zhongshan) University, Guangzhou, 510275, P. R. China ; |
| Abstract: | Paeciloxocins A and B (2-(1-hydroxy-3-methylbutyl)- and 2-(1-acetoxy-3-methylbutyl)- 11-hydroxy-9-methyl-1-methoxy-5H,7H-dibenzob,g]-1,5-dioxocin-5-ones), viz., two new metabolites, were isolated from the mangrove fungus Paecilomyces sp. collected from the Taiwan Strait. Their structures were elucidated by spectral methods. Paeciloxocin A exhibited strong cytotoxicity against the hepG2 cell line. |
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