Efficient palladium-catalyzed asymmetric allylic alkylation of ketones and aldehydes |
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Authors: | Zhao Xiaohu Liu Delong Xie Fang Liu Yangang Zhang Wanbin |
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Affiliation: | School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China. |
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Abstract: | Palladium-catalyzed asymmetric allylic alkylation of ketones, via enamines generated in situ as nucleophiles, were carried out smoothly with chiral metallocene-based P,N-ligands. Under the same conditions, however, reactions of aldehydes could hardly be observed. Subsequently, this obstacle was resolved by using chiral metallocene-based P,P-ligands. Both ketones and aldehydes afforded excellent enantioselectivities with up to 98% ee and 94% ee, respectively. |
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