Preparation of molecularly imprinted polymers for the selective recognition of the bioactive polyphenol, (E)-resveratrol |
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Authors: | Schwarz Lachlan J Danylec Basil Harris Simon J Boysen Reinhard I Hearn Milton T W |
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Affiliation: | Centre for Green Chemistry, Monash University, Clayton, 3800 Vic, Australia. |
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Abstract: | (E)-Resveratrol imprinted polymers have been rationally designed with the aid of molecular modelling and NMR spectroscopic titration techniques to determine the optimal ratio of the template to functional monomer for polymer formation. Based on this approach, (E)-resveratrol imprinted polymers were prepared via non-covalent self-assembly with the functional monomer 4-vinylpyridine (4VP) in a 1:3 molar ratio. Polymerisation in the presence of a cross-linker resulted in rigid block copolymers that had selective capacities towards (E)-resveratrol (e.g. 14 μmol/g) when compared to the non-imprinted reference polymer. The selectivity of these MIPs was also examined using several structurally related polyphenolic compounds to determine the influence of polyphenolic hydroxyl number and position on binding and molecular recognition. |
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Keywords: | Resveratrol Polyphenols Solid phase extraction Molecular modelling Molecularly imprinted polymers |
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