Amino Acid Derivatives, VI [1]: Synthesis, Antiviral, and Antimicrobial Evaluation of α-Amino Acid Esters Bearing a 1,2,3-Triazolo[4,5-d]pyrimidinedione Side Chain

Summary. A series of peptide and dipeptide derivatives conjugated with a 1,2,3-triazolo4,5-d]pyrimidinedione residue were synthesized. The new compounds were evaluated in vitro for cytotoxicity against HAV-27 and HSV-1 and showed moderate activity. The prepared compounds were tested for antimicrobial activity against four different bacterial species, and they displayed different degrees of antibacterial activities or inhibitory actions.