Synthesis,design, and antimicrobial activity of pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidinones based on quinoline derivatives |
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Authors: | Ameen A Abu-Hashem Mahmoud N M Yousif Abdel-Rhman Barakat Ahmed El-Gazzar Hend N Hafez |
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Institution: | Photochemistry Department (Heterocyclic Unit), National Research Centre, Giza, Egypt |
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Abstract: | The pyrido2,3-d]pyrimidine moieties are one of the most biologically widespread heterocyclic compounds as antimicrobial, antioxidant, antitubercular, antiviral and anti-inflammatory. Hence, we synthesized an efficient new series of 2-thioxo-pyrido2,3-d]pyrimidinone, 2-hydrazinyl-(quinolin-2-yl)pyrido2,3-d]pyrimidinone,N′-(quinolin-2-yl)-pyrido2,3-d]pyrimidine-(formo/aceto)-hydrazide and substituted-(quinolin-2-yl)pyrido2,3-d]1,2,4]triazolo4,3-a]pyrimidinone derivatives. The characterization of new compounds was corresponded by using spectroscopic techniques, IR, NMR and Mass spectra. In vitro, all compounds were evaluated as antimicrobial activity compared with cefotaxime sodium and nystatin as the standard drug. This work deals with the exploration of the new heterocyclic compounds and medicinal diversity of quinoline-pyrido2,3-d]1,2,4]triazolo4,3-a]pyrimidine derivatives that might pave the way for long in the discovery of therapeutic medicine for future drug design. |
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Keywords: | 1 2 4-triazole antimicrobial activity benzylidene-hydrazinyl hydrazide pyrido[2 3-d]pyrimidinone quinoline |
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