Ribozymes, genomics and therapeutics |
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| Authors: | Rossi J J |
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| Affiliation: | Department of Molecular Biology, Graduate School of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. |
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| Abstract: | Genome-sequencing projects are proceeding at a rapid pace and determining the function of open reading frames is the next great challenge. Ribozymes with site-specific cleaving activity could aid greatly in this process. High-throughput screening methods to identify optimal target sites for ribozyme cleavage will provide tools for functional genomics as well as therapeutic reagents. |
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