Boron complexes of S-trityl--cysteine and S-tritylglutathione |
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Authors: | Sandra Dí az, Asensio Gonz lez, Sandra Gonz lez de Riancho,Ana Rodrí guez |
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Affiliation: | Sandra Díaz, Asensio González, Sandra González de Riancho,Ana Rodríguez |
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Abstract: | S-Trityl--cysteine and S-tritylglutathione have been converted to 1,3,2-oxazaborolidine-5-ones by reaction with B-methoxydialkylborane derivatives. The synthesis of dicyclohexyl[S-trityl-(R)-cysteinato-O,N]boron (2), diisopinocampheyl[S-trityl-(R)-cysteinato-O,N]boron (3) and 9-borabicyclo[3.3.1]non-9-yl[S-tritylglutathionato-O,N]boron (5), dicyclohexyl[S-tritylglutathionato-O,N]boron (6) and diisopinocampheyl[S-tritylglutathionato-O,N]boron (7) from S-trityl--cysteine and S-tritylglutathione, respectively, with potential application in boron neutron capture therapy is reported. The structure of 9-borabicyclo[3.3.1]non-9-yl[S-trityl-(R)-cysteinato-O,N]boron 1 has been determined by X-ray diffraction. |
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Keywords: | Boron neutron capture therapy Cancer Glutathione |
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