Paper-based diagnostic platforms and devices |
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| Authors: | Mihaela Puiu Valentin Mirceski Camelia Bala |
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| Affiliation: | 1. R&D Center LaborQ, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018, Bucharest, Romania;2. Institute of Chemistry, Faculty of Natural Sciences and Mathematics, “Ss Cyril and Methodius” University, P.O. Box 162, 1000, Skopje, Macedonia;3. Department of Inorganic and Analytical Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Poland;4. Department of Analytical Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018, Bucharest, Romania |
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| Abstract: | Paper-based analytical devices have become lately “must have” components in equipment and instrumental designed for point-of-care applications, especially when they are used in tandem with microfluidic platforms. Nowadays, paper-based electrochemical devices (PEDs) represent the first choice in the development of lab-on-a-chip biosensors because of their benefits in biomedical diagnosis in terms of simplicity, affordability, portability, and disposability. Moreover, cellulose is a biodegradable and biocompatible substrate, ideal for building disposable devices for use in remote locations or low-resource settings. Despite their low costs and simplicity, PEDs must face a tough challenge—meeting the affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end users criteria. The latest achievements in microfluidic PEDs for clinical diagnosis will be critically discussed, putting emphasis on innovative assay formats and methods for surface modification. |
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| Keywords: | Paper devices Microfluidics Electrochemical biosensor Medical diagnostic Biomarker detection AFP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" α-fetoprotein (AFP)/AKD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" alkyl ketene dimer acpcPNA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" pyrrolidinyl peptide nucleic acid ASSURED" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" affordable sensitive" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" specific user-friendly" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" rapid and robust equipment-free and deliverable to end-users" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" Ag NW silver nanowire" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" ASV anodic stripping voltammetry" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" AuNP gold nanoparticle" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" CA 125 carcinoma antigen 125" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" CE counter electrode" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" CEA carcinoembryonic antigens" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" CL chemiluminescence" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" CNT carbon nanotube" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" CRP C reactive protein" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" DPV differential pulse voltammetry" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" ECL electrochemiluminescent" },{" #name" :" keyword" ," $" :{" id" :" kwrd0210" }," $$" :[{" #name" :" text" ," _" :" EIS electrochemical impedance spectroscopy" },{" #name" :" keyword" ," $" :{" id" :" kwrd0220" }," $$" :[{" #name" :" text" ," _" :" eLFA electrochemical lateral flow assay" },{" #name" :" keyword" ," $" :{" id" :" kwrd0230" }," $$" :[{" #name" :" text" ," _" :" ELISA enzyme-linked immunosorbent assay" },{" #name" :" keyword" ," $" :{" id" :" kwrd0240" }," $$" :[{" #name" :" text" ," _" :" EWOD electrowetting on dielectric" },{" #name" :" keyword" ," $" :{" id" :" kwrd0250" }," $$" :[{" #name" :" text" ," _" :" G graphene" },{" #name" :" keyword" ," $" :{" id" :" kwrd0260" }," $$" :[{" #name" :" text" ," _" :" GO graphene oxide" },{" #name" :" keyword" ," $" :{" id" :" kwrd0270" }," $$" :[{" #name" :" text" ," _" :" HBV hepatitis B virus" },{" #name" :" keyword" ," $" :{" id" :" kwrd0280" }," $$" :[{" #name" :" text" ," _" :" IFN-γ human interferon-gamma" },{" #name" :" keyword" ," $" :{" id" :" kwrd0290" }," $$" :[{" #name" :" text" ," _" :" LOC lab-on-a-chip" },{" #name" :" keyword" ," $" :{" id" :" kwrd0300" }," $$" :[{" #name" :" text" ," _" :" LOD limit of detection" },{" #name" :" keyword" ," $" :{" id" :" kwrd0310" }," $$" :[{" #name" :" text" ," _" :" MnSOD manganese super oxide dismutase" },{" #name" :" keyword" ," $" :{" id" :" kwrd0320" }," $$" :[{" #name" :" text" ," _" :" μPAD paper-based analytical device" },{" #name" :" keyword" ," $" :{" id" :" kwrd0330" }," $$" :[{" #name" :" text" ," _" :" OTS octadecyltrichlorosilane" },{" #name" :" keyword" ," $" :{" id" :" kwrd0340" }," $$" :[{" #name" :" text" ," _" :" PBB paper-based biosensors" },{" #name" :" keyword" ," $" :{" id" :" kwrd0350" }," $$" :[{" #name" :" text" ," _" :" p-CMF paper-based continuous flow microfluidic" },{" #name" :" keyword" ," $" :{" id" :" kwrd0360" }," $$" :[{" #name" :" text" ," _" :" PCR polymerase chain reaction" },{" #name" :" keyword" ," $" :{" id" :" kwrd0370" }," $$" :[{" #name" :" text" ," _" :" p-DMF paper-based digital microfluidic" },{" #name" :" keyword" ," $" :{" id" :" kwrd0380" }," $$" :[{" #name" :" text" ," _" :" PEAK1 pseudopodium-enriched atypical kinase 1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0390" }," $$" :[{" #name" :" text" ," _" :" PED paper-based electrochemical device" },{" #name" :" keyword" ," $" :{" id" :" kwrd0400" }," $$" :[{" #name" :" text" ," _" :" PEDOT poly (3,4-ethylenedioxythiophene) POC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0410" }," $$" :[{" #name" :" text" ," _" :" point-of-care PSS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0420" }," $$" :[{" #name" :" text" ," _" :" poly(styrenesulfonate) RBD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0430" }," $$" :[{" #name" :" text" ," _" :" receptor-binding domain RE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0440" }," $$" :[{" #name" :" 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}," $$" :[{" #name" :" text" ," _" :" World Health Organization |
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