Electrochemical sensors for oxidative stress monitoring |
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| Authors: | Aaditya S Deshpande Wayne Muraoka Silvana Andreescu |
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| Institution: | 1. Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA;2. U.S. Army Institute of Surgical Research, Blood and Shock Resuscitation, Fort Sam Houston, TX 78234, USA |
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| Abstract: | Electrochemical sensors are ideally suited for the detection of reactive oxygen and nitrogen species (ROS and RNS) generated during biological processes. This review discusses the latest work in the development of electrochemical microsensors for ROS/RNS and their applications for monitoring oxidative stress in biological systems. The performance of recent designs of microelectrodes and electrode materials is discussed along with their functionality in preclinical models of drug efficacy, mitochondrial distress, and endothelial dysfunction. Challenges and opportunities in translating this methodology to study the pathophysiology associated with various diseases are discussed. |
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| Keywords: | Oxidative stress ROS/RNS Nitric oxide Hydrogen peroxide Superoxide |
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