Visible light-induced hydroxyalkylation of 2H-benzothiazoles with alcohols via selectfluor oxidation |
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| Authors: | Yaolei Kong Wenxiu Xu Xinghai Liu Jianquan Weng |
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| Affiliation: | College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China |
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| Abstract: | A visible-light induced metal-free approach was described for the hydroxyalkylation of 2H-benzothiazoles with alcohols by using selectfluor as the oxidant. A variety of 2H-benzothiazoles and alcohols could be tolerated, providing a mild and simple method for the synthesis of C2-hydroxyalkylated 2H-benzothiazoles in moderate to good yields. Besides, ethers were also compatible in this reaction, leading to corresponding C2 ether-substituted 2H-benzothiazoles with high regioselectivity. |
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| Keywords: | Visible light-induced Hydroxyalkylation 2H-Benzothiazole Alcohol Selectfluor |
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