| Synthetic studies towards(-)-deserpidine:Total synthesis of the stereoisomer and derivative of (-)-deserpidine |
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| 作者姓名： | Pingzhou Wu Qilong Zhou Xiao-Yu Liu Fei Xue Yong Qin |
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| 作者单位： | Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China;; School of Pharmaceutical Sciences and the Innovative Drug Research Centre, Chongqing University, Chongqing 401331, China |
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| 基金项目： | We are grateful for the financial surpport from the National Natural Science Foundation of China (Nos. 21702140 and 21732005) and National Science and Technology Major Projects for “Major New Drugs Innovation and Development” (No. 2018ZX09101003-005-004). |
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| 摘 要： | The asymmetric synthesis of 16,17,20-epi-deserpidine and a derivative of(-)-deserpidine has been achieved.Key feature s in the assembly of the pentacyclic framework include a visible-light photocatalytic intra-/inter-/intramolecular radical cascade reaction to construct the tetracyclic ABCD ring system in one-pot and an intramolecularaldol reaction to forge the cyclohexane E ring.
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| 关 键 词： | Yohimbine alkaloids Deserpidine Photoredox catalytic radical cascade reaction Total synthesis |
| 收稿时间： | 26 November 2019 |
Synthetic studies towards (–)-deserpidine: Total synthesis of the stereoisomer and derivative of (–)-deserpidine |
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| Pingzhou Wu,Qilong Zhou,Xiao-Yu Liu,Fei Xue,Yong Qin.Synthetic studies towards(-)-deserpidine:Total synthesis of the stereoisomer and derivative of (-)-deserpidine[J].Chinese Chemical Letters,2021,32(1):401-404. |
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| Authors: | Pingzhou Wu Qilong Zhou Xiao-Yu Liu Fei Xue Yong Qin |
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| Institution: | Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; School of Pharmaceutical Sciences and the Innovative Drug Research Centre, Chongqing University, Chongqing 401331, China |
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| Abstract: | The asymmetric synthesis of 16,17,20-epi-deserpidine and a derivative of (–)-deserpidine has been achieved. Key features in the assembly of the pentacyclic framework include a visible-light photocatalytic intra-/inter-/intramolecular radical cascade reaction to construct the tetracyclic ABCD ring system in one-pot and an intramolecularaldol reaction to forge the cyclohexane E ring. |
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| Keywords: | Yohimbine alkaloids Deserpidine Photoredox catalytic radical cascade reaction Total synthesis |
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