An overview of polymeric nanomicelles in clinical trials and on the market |
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| Authors: | Xue Zheng Jizhen Xie Xing Zhang Weiting Sun Heyang Zhao Yantuan Li Cheng Wang |
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| Affiliation: | Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China; Shandong Center for Food and Drug Evaluation and Certification, Ji'nan 250013, China |
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| Abstract: | Polymeric nanomedicine is a promising and rapidly evolving field. Among the different polymeric carriers, polymeric micelle (PM) with nanoscale size exhibit potent physical and biological advantages including excellent solubility and pharmacokinetics, enhanced efficacy and lower toxicity. PM has garnered increasing interest in research and in the clinic. This review will highlight the clinical outcomes of several PM-based formulations, and further summarized their preparation methods, strengths and challenges. |
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| Keywords: | Polymeric micelles Drug delivery Preparation Clinical application Challenges |
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