| Synthesis of planar chiral isoquinolinone-fused ferrocenes through palladium-catalyzed C-H functionalization reaction |
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| 作者姓名： | Lantao Liu Huihui Liu Zhenzhen Zuo An-An Zhang Zhongyi Li Tuanjie Meng Wei Wu Yuanzhao Hua Guoliang Mao |
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| 作者单位： | Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China;; College of Chemistry and Chemical Engineering, Northeast Petroleum University, Daqing 163318, China;; Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry, Peking University, Beijing 100871, China;; College of Chemistry, Zhengzhou University, Zhengzhou 450001, China |
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| 基金项目： | We are grateful for the financial support from the National Natural Science Foundation of China (Nos. 21572126, 21202095, 14HASTIT016), Technicians Troop Construction Projects of Henan Province (No. C20150030), and Program of Science and Technology Innovation Talents of Henan Province (No. 184100510011). We would like to dedicate this work to Professor Li-Xin Dai for his 96th birthday. |
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| 摘 要： | (S,S)-Me-BI-DIME/Pd(0)-catalyzed ennantioselective C-H functionalization of N-ferrocenyl o-bromobenzanilides has been realized,affording isoquinolinone-fused ferrocenes with up to 97% ee.The products can be transformed into planar chiral ferrocenyl monophosphines,which demonstrate their preliminary application.
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| 关 键 词： | (S S)-Me-BI-DIME Palladium Asymmetric catalysis C-H functionalization Planar chiral ferrocenes |
| 收稿时间： | 10 September 2020 |
Synthesis of planar chiral isoquinolinone-fused ferrocenes through palladium-catalyzed C-H functionalization reaction |
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| Lantao Liu,Huihui Liu,Zhenzhen Zuo,An-An Zhang,Zhongyi Li,Tuanjie Meng,Wei Wu,Yuanzhao Hua,Guoliang Mao.Synthesis of planar chiral isoquinolinone-fused ferrocenes through palladium-catalyzed C-H functionalization reaction[J].Chinese Chemical Letters,2021,32(1):239-242. |
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| Authors: | Lantao Liu Huihui Liu Zhenzhen Zuo An-An Zhang Zhongyi Li Tuanjie Meng Wei Wu Yuanzhao Hua Guoliang Mao |
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| Institution: | Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China; College of Chemistry and Chemical Engineering, Northeast Petroleum University, Daqing 163318, China; Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry, Peking University, Beijing 100871, China; College of Chemistry, Zhengzhou University, Zhengzhou 450001, China |
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| Abstract: | (S,S)-Me-BI-DIME/Pd(0)-catalyzed ennantioselective C–H functionalization of N-ferrocenyl o-bromo-benzanilides has been realized, affording isoquinolinone-fused ferrocenes with up to 97% ee. The products can be transformed into planar chiral ferrocenyl monophosphines, which demonstrate their preliminary application. |
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| Keywords: | (S S)-Me-BI-DIME Palladium Asymmetric catalysis C-H functionalization Planar chiral ferrocenes |
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