| Substituent-regulated highly X-ray sensitive Os(Ⅵ)nitrido complex for low-toxicity radiotherapy |
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| 作者姓名： | Mingkai Chen Xiaoting Huang Jie Lai Li Ma Tianfeng Chen |
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| 作者单位： | Department of Chemistry, Jinan University, Guangzhou 510632, China |
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| 基金项目： | supported by the Natural Science Foundation of China(Nos.21701054,21877049);Guangdong Natural Science Foundation(No.2017A030310409);the Open Fund of the Key Laboratory of Functional Molecular Engineering of Guangdong Province(No.2017KF06);Major Program for Tackling Key Problems of Industrial Technology in Guangzhou(No.201902020013);Pearl River Nova Program of Guangzhou(No.201906010077);Dedicated Fund for Promoting High-Quality Marine Economic Development in Guangdong Province(Nos.GDOE-2019-A31,2020-035);Fundamental Research Funds for the Central Universities;Guangdong Provincial Key Laboratory Fund of Functional Supramolecular Coordination Materials and Applications;K.C.Wong Education Foundation。 |
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| 摘 要： | A high efficiency and low toxicity radiosensitizer,OsN(PhenOH)Cl_3,was designed and synthesized through substituent regulation.To the best of our knowledge,this is the first osmium-based coordination complex radiosensitizer.The experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction.
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| 关 键 词： | Os(Ⅵ)nitrido COMPLEX RADIOTHERAPY RADIOSENSITIZER G2/M cell cycle arrest |
| 收稿时间： | 10 September 2020 |
Substituent-regulated highly X-ray sensitive Os(VI) nitrido complex for low-toxicity radiotherapy |
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| Mingkai Chen,Xiaoting Huang,Jie Lai,Li Ma,Tianfeng Chen.Substituent-regulated highly X-ray sensitive Os(VI) nitrido complex for low-toxicity radiotherapy[J].Chinese Chemical Letters,2021,32(1):158-161. |
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| Authors: | Mingkai Chen Xiaoting Huang Jie Lai Li Ma Tianfeng Chen |
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| Institution: | Department of Chemistry, Jinan University, Guangzhou 510632, China |
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| Abstract: | A high efficiency and low toxicity radiosensitizer, OsN(PhenOH)Cl3, was designed and synthesized through substituent regulation. To the best of our knowledge, this is the first osmium-based coordination complex radiosensitizer. The experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction. |
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| Keywords: | Os(VI) nitrido Complex Radiotherapy Radiosensitizer G2/M cell cycle arrest |
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