Alcohols controlled selective radical cyclization of 1,6-dienes under mild conditions |
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| Authors: | Fu-Hua Qin Xun-Jie Huang Yi Liu Hongze Liang Qiang Li Zhong Cao Wen-Ting Wei Wei-Min He |
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| Institution: | State Key Laboratory Base of Novel Functional Materials and Preparation Science, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China; Institution of Functional Organic Molecules and Materials, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China; Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha 410114, China |
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| Abstract: | An efficient procedure for the selective preparation of hydroxy-, carbonyl- and acetal-containing 2-pyrrolidinones has been developed through radical cyclization of 1,6-dienes initiated by α-C(sp3)-H functionalization of alcohols. This protocol could be conducted at catalyst-free conditions at relatively low temperature (80 ℃) by employing commercially available tert-butyl peroxybenzoate (TBPB) as the oxidant. |
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| Keywords: | Green chemistry Metal free Cyclization Alcohol Pyrrolidinone |
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