Magnetofection: Magic magnetic nanoparticles for efficient gene delivery |
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Authors: | Qunjie Bi Xu Song Ao Hu Tianying Luo Rongrong Jin Hua Ai Yu Nie |
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Institution: | National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; Institute of Regulatory Science for Medical Devices, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China |
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Abstract: | Magnetic nanoparticles (MNPs) have become a research hotspot and widely used in the biomedical field in recent decades due to their unique magnetic properties. This minireview summarizes the specific gene transfection of magnetic particles (magnetofection) during eversy dynamic process of gene delivery (gene binding, cellular uptake, endosomal escape, intracellular trafficking and in vivo targeting). Meanwhile, the synergistic biomedical application of magnetofection and the effects of MNPs have also been discussed, including magnetic resonance imaging (MRI), magnetic mediated hyperthermia (MMH), Fenton reaction and autophagy. Finally, the clinical prospect of magnetofection was briefly expected. |
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Keywords: | Magnetic nanoparticles Magentofection Gene therapy Biomedical applications Combined therapy |
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