Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3 |
| |
Authors: | Pengzhan Wang Huocheng Yang Chang Liu Mingqiang Qiu Xin Ma Zhiqiang Mao Yao Sun Zhihong Liu |
| |
Affiliation: | 1. Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China;2. State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Xinjiang 830011, China;3. International Joint Research Center for Intelligent Biosensor Technology and Health, Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China;4. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
| |
Abstract: | Caspases are a family of proteases that play critical roles in controlling inflammation and cell death. Apoptosis is a caspase-3 mainly controlled behavior to avoid inflammation and damage to surrounding cells, whereas anomalistic cell apoptosis may be associated with many diseases. The detection and imaging of caspase-3 will be of great significance in evaluating the early therapeutic effect of tumors. Developing smart fluorescent probes may be helpful for the visualization of therapeutic effect compared with “always on” probes. Thus, more and more works toward activatable fluorescent probes for caspase-3 imaging have been reported. In addition, multifunctional probes have also been designed to further improve the imaging of caspase-3. Herein, this review systematically summarized the representative work of caspase-3 from the perspective of molecular design that it will play a guiding role in the design of probes that respond to caspase-3. Also, challenges and perspectives toward the field for imaging of cell apoptosis (caspase-3) are also discussed. |
| |
Keywords: | Fluorescence imaging Multi-functional Activatable probe Caspase-3 |
本文献已被 CNKI 维普 ScienceDirect 等数据库收录! |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
|
点击此处可从《中国化学快报》下载全文 |
|