A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery |
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| Authors: | Shuai Guo Bei Liu Mengjie Zhang Chunhui Li Xiaoxia Wang Yuhua Weng Lele Li Yuanyu Huang |
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| Affiliation: | 1. School of Life Science, Advanced Research Institute of Multidisciplinary Science, Key Laboratory of Molecular Medicine and Biotherapy, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China;2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China;3. School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;4. College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China;5. Hunan University of Science and Engineering, Yongzhou 425199, China;6. Institute of Molecular Medicine, Peking University, Beijing 100871, China |
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| Abstract: | Despite the promising prospect of small interfering RNA (siRNA) for the treatment of diverse diseases, it remains challenging to develop novel delivery materials to desired tissues and cells. In this study, a novel iron oxyhydroxide (FeOOH) nanoparticle (NP) whose surface was modified with branched polyether-imide (PEI) was developed to deliver siRNA into the cancer cells. It was demonstrated that PEI-FeOOH (PFeOOH) efficiently complexed siRNA, mediated effective cellular uptake and endosomal escape, thereby triggering robust gene silencing in vitro. In addition, PFeOOH/siRNA formulation loading with anti-RRM2 siRNA effectively inhibited the growth of tumor tissues, and exhibited excellent safety profiles in vivo. Therefore, this study conceptually provided a FeOOH-based nucleic acid delivery vesicle which can potentially use to achieve diagnosis and therapy simultaneously. |
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| Keywords: | FeOOH siRNA delivery RRM2 RNA interference Polyetherimide Cancer treatment |
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