Self-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications |
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Authors: | Dongjie Fu Dingchang Liu Lianbing Zhang Leming Sun |
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Institution: | School of Life Sciences, Key Laboratory of Space Bioscience & Biotechnology, Northwestern Polytechnical University, Xi'an 710072, China |
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Abstract: | Peptide self-assembled nanomaterials have attracted more and more attention due to their wide applications such as drug delivery, cell imaging, and real-time drug monitoring. However, the application of the peptide is still limited by its inherent optical properties. Here we proposed and prepared a series of fluorescent tripeptide nanoparticles (TPNPs) through π-π stacking and zinc coordination. The experimental results show that the nanoparticles (TPNPs1) formed by the self-assembly of the tripeptide tryptophan-tryptophan-tryptophan have the highest fluorescence intensity, uniform and appropriate size, and low cytotoxicity. Furthermore, there was fluorescence resonance between TPNPs1 and doxorubicin, which has been successfully applied for real-time cell imaging and drug release monitoring. |
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Keywords: | Self-assembly Tripeptide Fluorescent nanoparticles Bioimaging Doxorubicin Drug delivery |
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