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Enantiomer separation of side-chain fluorinated alkylbenzenes by capillary gas chromatography on cyclodextrin phases |
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| Authors: | R. Reinhardt W. Engewald O. Goj G. Haufe |
| Affiliation: | (1) Institut für Analytische Chemie, Universität Leipzig, Linnéstraße 3, 04103 Leipzig, Germany;(2) Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, corrensstraße 40, 48149 Münster, Germany;(3) Present address: Institut für Pharmakologie und Toxikologie, Universität Leipzig, Härtelstraße 16-18, 04107 Leipzig, Germany |
| Abstract: | Summary The separation of racemic side-chain fluorinated alkylbenzenes and bromofluorinated analogues by capillary gas chromatography using permethylated  ,  and  -cyclodextrins dissolved in polysiloxanes of different polarity as stationary phases is described. The influence of the achiral polysiloxane matrices on the separation of enantiomers is discussed in the light of the results obtained with the different phases. For a part of the tested compounds thermodynamic data are determined which describe the interaction of enantiomers with the stationary phase. The mechanism of separation is discussed on this basis and by comparison with data for structurally similar compounds. |
| Keywords: | Gas chromatography Enantiomer separation Permethylated cyclodextrin stationary phases Side-chain fluorinated alkylbenzenes Thermodynamic data |
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