| 一类Fmoc保护二肽醇类凝胶因子的合成与凝胶化研究 |
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| 引用本文： | 谢志国,张爱英,叶霖,冯增国.一类Fmoc保护二肽醇类凝胶因子的合成与凝胶化研究[J].化学学报,2008,66(23):2620-2624. |
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| 作者姓名： | 谢志国 张爱英 叶霖 冯增国 |
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| 作者单位： | (北京理工大学材料科学与工程学院， 北京 110000008811) |
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| 摘 要： | 合成了一类Fmoc保护二肽凝胶因子(Fmoc-Lys(Fmoc)-Tyr-OR, R=＝Me, Et, Hex)，, 并通过加热溶解-冷却静置方法测试了其凝胶性能。. 它们可在多种脂肪醇类溶剂中形成有机凝胶，, 并且具有热可逆性。. 通过透射电镜发现，, R为Me的凝胶因子在正己醇中可自组装成纳米级纤维状结构，, 相互交织使溶剂得以固定形成半透明凝胶，, 而在正丙醇中则倾向自组装成多刺球状，, 形成不透明白色凝胶。. IR及荧光光谱分析结果表明氢键与π-π stacking作用参与了其凝胶化自组装，, 同时氢键在凝胶态的强度较其固态时降低。. 该结果也从XRD数据中得以进一步证实。
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| 关 键 词： | 凝胶因子 Fmoc保护二肽 自组装 |
| 收稿时间： | 2008-5-21 |
| 修稿时间： | 2008-7-7 |
Synthesis and Gelation of a Series of Low-molecular-weight Gelators based on Fmoc-dipeptide in Alcoholic Solvents |
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| XIE,Zhi-Guo,ZHANG,Ai-Ying,YE,Lin,FENG,Zeng-Guo.Synthesis and Gelation of a Series of Low-molecular-weight Gelators based on Fmoc-dipeptide in Alcoholic Solvents[J].Acta Chimica Sinica,2008,66(23):2620-2624. |
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| Authors: | XIE Zhi-Guo ZHANG Ai-Ying YE Lin FENG Zeng-Guo |
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| Institution: | (Department of Material Science and Engineering,, Beijing Institute of Technology,, Beijing 11000008811) |
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| Abstract: | A series of Fmoc-Lys(Fmoc)-Tyr-OR (R=＝Me, Et, Hex) gelators were synthesized and characterized, which were found to gelate a number of aliphatic alcohols to give translucent or opaque thermo-reversible organogels. Nanofiber and spherulitic networks were evidenced in the self-assemblies in n-hexanol and n-propanol by TEM, respectively. IR and fluorescence studies revealed that the hydrogen bonding and π-π stacking acted as a significant driving force for the self-assembly. As a result, the intensity of hydrogen bonding in xerogel was lower than that in the solid, which was further confirmed by XRD analyses. |
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| Keywords: | gelator Fmoc-dipeptide self-assembly |
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