The complexes of metal ions with fluoroquinolones |
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Authors: | A Serafin A Stańczak |
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Institution: | (1) Department of Hospital Pharmacy, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland |
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Abstract: | Fluoroquinolones are defined as an important group of synthetic antibacterial compounds, having a fluorine atom at position
6 and a piperazine ring at position 7 of quinolone-3-carboxylic acid. It was proved that the activity of quinolones was decreased
in the environment of certain metal ions by the formation of sparingly soluble metal complexes. The proposed reason for such
maintenance might be the chelate bonding of the quinolone to the metal. Again, it was proposed that metal ions, especially
magnesium ions, were engaged in the mode of action of quinolones. In this review article, selected structures of fluoroquinolones
metal complexes were performed and discussed in terms of their therapeutic application. The nuclease activity and antibacterial
activity tests were presented and the effects of metal complexes were compared to free fluoroquinolones. Finally, the results
were introduced.
The article is published in the original. |
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