| Preparation of Platinum(II) Complexes with 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide and its Deoxy-analogue |
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| 作者姓名： | Wen PEI* Kobe JOZE College of Chemical Engineering Zhejiang University of Technology Hangzhou National Institute of Chemistry Hajdrihova SI- Ljubljana Slovenia |
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| 作者单位： | Wen PEI1*，Kobe JOZE2 1College of Chemical Engineering，Zhejiang University of Technology，Hangzhou 310014 2National Institute of Chemistry，Hajdrihova 19，SI-1115 Ljubljana，Slovenia |
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| 摘 要： | Much attention is currently focused on the design of new generations of platinum anti-cancer complexes to prevent resistance of cisplatin. We have developed a new platinum-based antitumor agent with broad-spectrum antiviral activity. The cis-Pt(DMSO)2Cl2] and KPt (DMSO) Cl3] reacted with 1-??-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and its deoxy-analogue (deoxyribavirin) to give the coordinated complexes which exhibited activity against both DNA and RNA viruses1. The…
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